UBTF Antibody
CATALOG NUMBER: 56-496- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This UBTF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-660 amino acids from the C-terminal region of human UBTF.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 89 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: UBTF
- ADDITIONAL NAMES: Nucleolar transcription factor 1, Autoantigen NOR-90, Upstream-binding factor 1, UBF-1, UBTF, UBF, UBF1
- Protein Accession Number: P17480
- PROTEIN GI NUMBER: 136652
- NCBI GENE ID NUMBER: 7343
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Upstream binding factor (UBF) is a transcription factorrequired for expression of the 18S, 5.8S, and 28S ribosomal RNAs,along with SL1 (a complex of TBP (MIM 600075) and multipleTBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBFis a nucleolar phosphoprotein with both DNA binding andtransactivation domains. Sequence-specific DNA binding to the coreand upstream control elements of the human rRNA promoter ismediated through several HMG boxes (Jantzen et al., 1990 [PubMed2330041]).
- 1: Hisaoka, M., et al. Mol. Cell. Biol. 30(20):4952-4964(2010)
- 2: Liu, Z., et al. Proteins 77(2):432-447(2009)
- 3: Lin, C.I., et al. Biochem. Biophys. Res. Commun. 386(2):396-401(2009)
- 4: Grob, A., et al. J. Cell. Sci. 122 (PT 4), 489-498 (2009) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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