- Trial Size
TSLP Receptor Antibody
CATALOG NUMBER: 4207- Clonality: Polyclonal
- Tested Applications: ELISA, IF, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat: (73%)
- IMMUNOGEN: TSLP Receptor antibody was raised against a 19 amino acid synthetic peptide from near the center of human TSLP receptor.
The immunogen is located within amino acids 140 - 190 of TSLP Receptor. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
- APPLICATION NOTE: TSLP-R antibody can be used for detection of TSLP-R by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - SPECIFICITY: At least two isoforms of TSLP-R are known to exist; this antibody will recognize both isoforms.
- POSITIVE CONTROL 1: Cat. No. 1304 - Human Liver Tissue Lysate
- POSITIVE CONTROL 2: Cat. No. 10-201 - Human Liver Tissue Slide
- PREDICTED MOLECULAR WEIGHT: Predicted: 28, 41 kDa
Observed: 53 kDa
Properties
- PURIFICATION: TSLP Receptor Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: TSLP Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: Crlf2
- ADDITIONAL NAMES: TSLP Receptor Antibody: CRLM2, Ly114, Tpte2, Tslpr, Crlm2, Cytokine receptor-like factor 2, Cytokine receptor-like molecule 2, CRLM-2
- Protein Accession Number: NP_071431
- PROTEIN GI NUMBER: 19923096
- NCBI GENE ID NUMBER: 57914
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
- 1: Ziegler SF and Liu Y-J. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nature Immunol. 2006; 7:709-14.
- 2: Sims JE, Williams DE, Morrissey PJ, et al. Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J. Exp. Med. 2000; 192:671-80.
- 3: Levin SD, Koelling RM, Friend SL, et al. Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ cells in vitro and signals via a novel mechanism. J. Immunol. 1999; 162:677-83.
- 4: Park LS, Martin U, Garka K, et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 2000; 192:659-70.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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