TSG101 Antibody
CATALOG NUMBER: 61-117- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse, Rat
- IMMUNOGEN: This TSG101 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-370 amino acids from the C-terminal region of human TSG101.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 44 kDa
Properties
- PURIFICATION: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: TSG101
- ADDITIONAL NAMES: Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
- Protein Accession Number: Q99816
- PROTEIN GI NUMBER: 9789790
- NCBI GENE ID NUMBER: 7251
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
- 1: Favre, M., et al., J. Acquir. Immune Defic. Syndr. 34(2):127-133 (2003).
- 2: Lu, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 100(13):7626-7631 (2003).
- 3: Goila-Gaur, R., et al., J. Virol. 77(11):6507-6519 (2003).
- 4: Blanco, S., et al., FEMS Microbiol. Lett. 221(2):151-154 (2003).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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