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TRPV1 Antibody
CATALOG NUMBER: 7179- Clonality: Polyclonal
- Tested Applications: E, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Guinea pig: (81%), Mouse: (75%)
- IMMUNOGEN: Rabbit polyclonal TRPV1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TRPV1.
The immunogen is located within the last 50 amino acids of TRPV1. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: TRPV1 antibody can be used for detection of TRPV1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. - POSITIVE CONTROL 1: Cat. No. 1204 - K562 Cell Lysate
- PREDICTED MOLECULAR WEIGHT: Predicted: 92 kDa
Properties
- PURIFICATION: TRPV1 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: TRPV1 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: TRPV1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: TRPV1
- ADDITIONAL NAMES: TRPV1 Antibody: VR1, VR1, Transient receptor potential cation channel subfamily V member 1, Capsaicin receptor, TrpV1
- Protein Accession Number: NP_542437
- PROTEIN GI NUMBER: 74315354
- NCBI GENE ID NUMBER: 7442
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- TRPV1 Antibody: TRPV1 is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
- 1: Eid SR and Cortright DN. Transient receptor potential channels on sensory nerves. Handb. Exp. Pharmacol. 2009; 194:261-81.
- 2: Minke B and Cook B. TRP channel proteins and signal transduction. Physiol. Rev. 2002; 82:429-72.
- 3: Planells-Cases R, Valente P, Ferrer-Montiel A, et al. Complex regulation of TRPV1 and related thermo-TRPs: implications for therapeutic intervention. Adv. Exp. Med. Biol. 2011; 704:491-515.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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