TOP3B Antibody
CATALOG NUMBER: 58-713- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- IMMUNOGEN: This TOP3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-854 amino acids from the C-terminal region of human TOP3B.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 97 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: TOP3B
- ADDITIONAL NAMES: DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B, TOP3B1
- Protein Accession Number: O95985
- NCBI GENE ID NUMBER: 8940
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This enzyme catalyzes the transient breaking andrejoining of a single strand of DNA which allows the strands topass through one another, thus relaxing the supercoils and alteringthe topology of DNA. The enzyme interacts with DNA helicase SGS1and plays a role in DNA recombination, cellular aging andmaintenance of genome stability. Alternative splicing of theC-terminus of this gene results in three transcript variants whichhave distinct tissue specificity; however, not all variants havebeen fully described.
- 1: Oliveira-Costa, J.P., et al. Hum. Pathol. 41(11):1624-1630(2010)
- 2: Lesch, K.P., et al.Neural Transm 115(11):1573-1585(2008)
- 3: Cho, Y.H., et al. Biochim. Biophys. Acta 1679(3):272-278(2004)
- 4: Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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