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TMEM41B (NT) Antibody
CATALOG NUMBER: 9567- Clonality: Polyclonal
- Tested Applications: E, IF, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Horse (100%); Chimpanzee (100%).
- IMMUNOGEN: Anti-TMEM41B antibody (9567) was raised against a peptide corresponding to 11 amino acids near the amino terminus of human TMEM41B.
The immunogen is located within the first 50 amino acids of TMEM41B. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, WB
- APPLICATION NOTE: WB: 2 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human, mouse, and rat samples; Immunofluorescence in human, mouse and rat samples. All other applications and species not yet tested. - POSITIVE CONTROL 1: Cat. No. 1203 – A549 Cell Lysate
- POSITIVE CONTROL 2: Cat. No. 17-001 - HeLa Cell Slide
- PREDICTED MOLECULAR WEIGHT: Predicted: 33kD
Observed: 33 kD
Properties
- PURIFICATION: TMEM41B Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: TMEM41B Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: TMEM41B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: TMEM41B
- ADDITIONAL NAMES: TMEM41B Antibody: Transmembrane protein 41B, Protein stasimon, TMEM41B, KIAA0033.
- Protein Accession Number: Q5BJD5
- PROTEIN GI NUMBER: 74741383
- NCBI GENE ID NUMBER: 440026
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- TMEM41B Antibody: TMEM41B is required for autophagosome formation and participates in early stages of autophagosome biogenesis at the ER membrane probably via mobilization of neutral lipids from lipid droplets. TMRM41B is a critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus. It is required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles.
- 1: Moretti et al. EMBO Rep. 2018; 19(9):e45889.
- 2: Shoemaker et al. PLoS Biol. 2019; 17(4):e2007044.
- 3: Schneider et al. Cell 2021; 184(1):120-132.
- 4: Hoffmann et al. Cell 2021; 184(1):133-148.e20.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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