- Trial Size
TLX2 Antibody
CATALOG NUMBER: 7373- Clonality: Polyclonal
- Tested Applications: E, IF, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: TLX2 antibody was raised against an 18 amino acid peptide near the amino terminus of human TLX2.
The immunogen is located within amino acids 20 - 70 of TLX2. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, IHC-P, WB
- APPLICATION NOTE: TLX2 antibody can be used for detection of TLX2 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. - SPECIFICITY: TLX2 antibody is predicted to not cross-react with other TLX proteins.
- POSITIVE CONTROL 1: Cat. No. 1463 - Rat Brain Tissue Lysate
- PREDICTED MOLECULAR WEIGHT: Predicted: 31 kDa
Observed: 30 kDa
Properties
- PURIFICATION: TLX2 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: TLX2 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: TLX2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: TLX2
- ADDITIONAL NAMES: TLX2 Antibody: NCX, HOX11L1, NCX, T-cell leukemia homeobox protein 2, Homeobox protein Hox-11L1
- Protein Accession Number: NP_057254
- PROTEIN GI NUMBER: 7706621
- NCBI GENE ID NUMBER: 3196
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- TLX2 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX2, also known as homeobox11-like 1 (HOX11L1), is a DNA-binding nuclear transcription factor that appears to be crucial for the development of the peripheral nervous system. TLX2 is a downstream target of regulation by both PHOX2A and PHOX2B proteins during intestinal neuronal differentiation. In humans, loss-of-function of TLX2 may play a role in tumorigenesis of gastrointestinal stromal tumors.
- 1: Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
- 2: Puliti A, Cinti R, Betsos N, et al. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1>p12 and mouse chromosome 6C3-D1. Cytogenet. Cell Genet. 1999; 84:115-7.
- 3: Borghini S, Di Duca M, Santamaria G, et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur. J. Human Genet. 2007; 15:848-55.
- 4: Borghini S, Bachetti T, Fava M, et al. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural crest derived cells. Biochem. J. 2006; 395:355-61.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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