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TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
TIGIT Antibody [4A11]
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TIGIT Antibody [4A11]

CATALOG NUMBER: RF16055
  • Clonality: Monoclonal
  • Tested Applications: ELISA, Flow, ICC, IF, IHC-P, WB
  • Host Species: Mouse
  • Species Reactivity: Human
  • Conjugate: Unconjugated
  • Size: 0.02 mg | 0.1 mg

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Human
  • IMMUNOGEN: TIGIT antibody was raised against the extracellular domain of human TIGIT
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: ELISA, Flow, ICC, IF, IHC-P, WB
  • APPLICATION NOTE: TIGIT antibody can be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 1 μg/mL. For flow cytometry at 1 μg/ml. For immunocytochemistry at 1 μg/mL. For Western blot at 1 μg/mL.
    Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples; Immunocytochemistry in human samples; Immunofluorescence in human samples and Flow Cytometry in human samples. All other applications and species not yet tested.
  • POSITIVE CONTROL 1: Cat. No. 1340 - Human Stomach Carcinoma Tissue Lysate
  • PREDICTED MOLECULAR WEIGHT: Predicted: 26 kDa
    Observed: 47 kDa

Properties

  • PURIFICATION: TIGIT Antibody is supplied as protein A purified IgG1.
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG1
  • PHYSICAL STATE: Liquid
  • BUFFER: TIGIT Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
  • CONCENTRATION: 1 mg/mL
  • STORAGE CONDITIONS: TIGIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

  • NCBI OFFICIAL SYMBOL: TIGIT
  • ADDITIONAL NAMES: TIGIT Antibody: T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM
  • Protein Accession Number: NP_776160
  • PROTEIN GI NUMBER: 256600228
  • NCBI GENE ID NUMBER: 201633
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).
  • 1: Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009; 106:17858-63.
  • 2: Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell 2014; 26:923-37.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: RF16055

  • Size: 0.02 mg | 0.1 mg
  • List Price: $89.00 – $459.00
Datasheet
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