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Thyroglobulin Antibody [TGB24]Thyroglobulin Antibody [TGB24]
Thyroglobulin Antibody [TGB24]
Thyroglobulin Antibody [TGB24]

Thyroglobulin Antibody [TGB24]

CATALOG NUMBER: 33-466
  • Clonality: Monoclonal
  • Tested Applications: Flow, IHC-P, WB
  • Host Species: Mouse
  • Species Reactivity: Human
  • Conjugate: Unconjugated
  • Size: 100 ug

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Human
  • IMMUNOGEN: Human thyroid follicular cells were used as the immunogen for the TG antibody.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: Flow, IHC-P, WB
  • APPLICATION NOTE: Flow Cytometry (0.5-1 ug/million cells in 0.1ml)
    Immunohistochemistry (FFPE): 0.5-1 ug/ml for 30 min at RT (1)
    Prediluted format: incubate for 30 min at RT (2)
    Optimal dilution of the TG antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Properties

  • PURIFICATION: Protein G affinity chromatography
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG1, kappa
  • PHYSICAL STATE: Liquid
  • BUFFER: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
  • CONCENTRATION: 0.2 mg/mL
  • STORAGE CONDITIONS: Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.

Additional Info

  • NCBI OFFICIAL SYMBOL: TG
  • ADDITIONAL NAMES: TG, AITD3, TDH3, Thyroglobulin, TGN
  • NCBI GENE ID NUMBER: 7038
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher

Background

  • Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 33-466

  • Size: 100 ug
  • List Price: $555.00
Datasheet
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