TEF Antibody
CATALOG NUMBER: 60-382- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken, Rat
- IMMUNOGEN: This TEF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-240 amino acids from the C-terminal region of human TEF.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 33 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: TEF
- ADDITIONAL NAMES: Thyrotroph embryonic factor, TEF, KIAA1655
- Protein Accession Number: Q10587
- PROTEIN GI NUMBER: 51338730
- NCBI GENE ID NUMBER: 7008
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Thyrotroph embryonic factor (TEF), a transcription factor,is a member of the PAR (proline and acidic amino acid-rich)subfamily of basic region/leucine zipper (bZIP) transcriptionfactors. It is expressed in a broad range of cells and tissues inadult animals, however, during embryonic development, TEFexpression appears to be restricted to the developing anteriorpituitary gland, coincident with the appearance ofthyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to,and transactivate the TSHB promoter. It shows homology (in thefunctional domains) with other members of the PAR-bZIP subfamily oftranscription factors, which include albumin D box-binding protein(DBP), human hepatic leukemia factor (HLF) and chicken vitellogeningene-binding protein (VBP); VBP is considered the chicken homologueof TEF. Different members of the subfamily can readily formheterodimers, and share DNA-binding, and transcriptional regulatoryproperties. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
- 1: Kripke, D.F., et al. Psychiatry Investig 7(1):36-42(2010)
- 2: Inukai, T., et al. Blood 105(11):4437-4444(2005)
- 3: Collins, J.E., et al. Genome Biol.(10), R84 (2004) :
- 4: Newman, J.R., et al. Science 300(5628):2097-2101(2003)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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