- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: Tau (Phospho-Ser404) antibody was raised against a peptide sequence around phosphorylation site of serine 404 (D-T-S (p) -P-R) derived from Human Tau.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
- SPECIFICITY: This antibody detects endogenous level of Tau only when phosphorylated at serine 404.
- PREDICTED MOLECULAR WEIGHT: 48, 62, 78 kDa
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
- NCBI OFFICIAL SYMBOL: MAPT
- ADDITIONAL NAMES: TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, MAPT, MTAPT, Neurofibrillary tangle protein, PHF-tau
- Protein Accession Number: NP_001116538.1
- PROTEIN GI NUMBER: 178557734
- NCBI GENE ID NUMBER: 4137
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- 1: Li G, Yin H, et. al . (2004) J Biol Chem ; 279 (16): 15938-45. Noble W, et al. (2003) Neuron ; 38 (4): 555-65. Giasson BI, et al. (2002) . Biochemistry; 41 (51): 15376-87. Lee G., et. al. (1989) . Neuron 2:1615-1624. Andreadis A. et. al. (1992) Biochemistry 31:10626-10633.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 79-153
- Size: 0.1 mg
- List Price: $325.00
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