Tau (Ab 214) Antibody
CATALOG NUMBER: 79-541- Clonality: Polyclonal
- Tested Applications: IF
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: Tau (Ab-214) antibody was raised against a peptide sequence around aa.212~216 (T-P-S-L-P) derived from Human Tau.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF
- APPLICATION NOTE: Immunofluorescence: 1:100~1:200
- SPECIFICITY: This antibody detects endogenous level of total Tau protein.
- PREDICTED MOLECULAR WEIGHT: 48, 62, 78 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: MAPT
- ADDITIONAL NAMES: TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, MAPT, MTAPT, Neurofibrillary tangle protein, PHF-tau
- Protein Accession Number: NP_001116538.1
- PROTEIN GI NUMBER: 178557734
- NCBI GENE ID NUMBER: 4137
Background
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- 1: Smet C, et al. (2005) FEBS Lett; 579 (19): 4159-64. Puig B, et al. (2005) Acta Neuropathol (Berl) . Gvtz J, et al. (2001) Science; 293 (5534): 1491-5. Illenberger S, et al. (1998) Mol Biol Cell; 9 (6): 1495-512.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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