- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: SYNGR1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human SYNGR1.
The immunogen is located within amino acids 120 - 170 of SYNGR1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, IHC-P, WB
- APPLICATION NOTE: SYNGR1 antibody can be used for detection of SYNGR1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
- POSITIVE CONTROL 1: Cat. No. 1463 - Rat Brain Tissue Lysate
- PURIFICATION: SYNGR1 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: SYNGR1 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: SYNGR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- NCBI OFFICIAL SYMBOL: SYNGR1
- ADDITIONAL NAMES: SYNGR1 Antibody: Synaptogyrin-1
- Protein Accession Number: CAA05322
- PROTEIN GI NUMBER: 2959866
- NCBI GENE ID NUMBER: 9145
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
- SYNGR1 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. The gene for SYNGR1is located at chromosome 22q13, a region linked to schizophrenia; however, there is mixed evidence suggesting that mutations in SYNGR1 might be associated with schizophrenia.
- 1: Kedra D, Pan HQ, Seroussi E, et al. Characterization of the human synaptogyrin gene family. Hum. Genet.1998; 103:131-41.
- 3: Cheng MC and Chen CH. Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia. J. Psychiatr. Res.2007; 41:1027-31.
- 4: Wang Y, Yu L, Zhao T, et al. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. Psychiatry Res.2009; 169:167-8.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 5563
- Size: 0.02 mg | 0.1 mg
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