ST14 Antibody
CATALOG NUMBER: 62-196- Clonality: Polyclonal
- Tested Applications: IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- IMMUNOGEN: This ST14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-855 amino acids from the C-terminal region of human ST14.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 95 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ST14
- ADDITIONAL NAMES: Suppressor of tumorigenicity 14 protein, Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein, ST14, PRSS14, SNC19, TADG15
- Protein Accession Number: Q9Y5Y6
- PROTEIN GI NUMBER: 13124575
- NCBI GENE ID NUMBER: 6768
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
- 1: Santin, A.D., et al., Cancer 98(9):1898-1904 (2003).
- 2: Oberst, M.D., et al., J. Biol. Chem. 278(29):26773-26779 (2003).
- 3: Ihara, S., et al., J. Biol. Chem. 277(19):16960-16967 (2002).
- 4: Benaud, C.M., et al., Clin. Exp. Metastasis 19(7):639-649 (2002).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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