SSX4 Antibody
CATALOG NUMBER: 56-923- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This SSX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human SSX4.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 22 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: SSX4
- ADDITIONAL NAMES: Protein SSX4, Cancer/testis antigen 54, CT54, SSX4, SSX4A
- Protein Accession Number: O60224
- NCBI GENE ID NUMBER: 5483136759
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The product of this gene belongs to the family of highlyhomologous synovial sarcoma X (SSX) breakpoint proteins. Theseproteins may function as transcriptional repressors. They are alsocapable of eliciting spontaneously humoral and cellular immuneresponses in cancer patients, and are potentially useful targets incancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes havebeen involved in the t(X;18) translocation characteristically foundin all synovial sarcomas. This translocation results in the fusionof the synovial sarcoma translocation gene on chromosome 18 to oneof the SSX genes on chromosome X. Chromosome Xp11 contains asegmental duplication resulting in two identical copies of synovialsarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tailorientation. This gene, SSX4B, represents the more centromericcopy. Two transcript variants encoding distinct isoforms have beenidentified for this gene.
- 1: Ayyoub, M., et al. J. Immunol. 174(8):5092-5099(2005)
- 2: Ross, M.T., et al. Nature 434(7031):325-337(2005)
- 3: Gure, A.O., et al. Int. J. Cancer 101(5):448-453(2002)
- 4: Brodin, B., et al. Gene 268 (1-2), 173-182 (2001) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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