Specifications
- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This SSRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the C-terminal region of human SSRP1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 81 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: SSRP1
- ADDITIONAL NAMES: FACT complex subunit SSRP1, Chromatin-specific transcription elongation factor 80 kDa subunit, Facilitates chromatin transcription complex 80 kDa subunit, FACT 80 kDa subunit, FACTp80, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1, Structure-specific recognition protein 1, hSSRP1, T160, SSRP1, FACT80
- Protein Accession Number: Q08945
- NCBI GENE ID NUMBER: 6749
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene is a subunit of aheterodimer that, along with SUPT16H, forms chromatintranscriptional elongation factor FACT. FACT interacts specificallywith histones H2A/H2B to effect nucleosome disassembly andtranscription elongation. FACT and cisplatin-damaged DNA may becrucial to the anticancer mechanism of cisplatin. This encodedprotein contains a high mobility group box which most likelyconstitutes the structure recognition element forcisplatin-modified DNA. This protein also functions as aco-activator of the transcriptional activator p63. An alternativelyspliced transcript variant of this gene has been described, but itsfull-length nature is not known.
- 1: Zeng, S.X., et al. Mol. Cell. Biol. 30(4):935-947(2010)
- 2: Hautbergue, G.M., et al. Curr. Biol. 19(22):1918-1924(2009)
- 3: Hu, J., et al. J. Virol. 83(21):11051-11063(2009)
- 4: Kumari, A., et al. J. Cell. Biochem. 108(2):508-518(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.