SPOP Antibody
CATALOG NUMBER: 60-100- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Zebrafish, Mouse
- IMMUNOGEN: This SPOP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the N-terminal region of human SPOP.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 42 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: SPOP
- ADDITIONAL NAMES: Speckle-type POZ protein, HIB homolog 1, Roadkill homolog 1, SPOP
- Protein Accession Number: O43791
- NCBI GENE ID NUMBER: 8405
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a protein that may modulate thetranscriptional repression activities of death-associated protein 6(DAXX), which interacts with histone deacetylase, core histones,and other histone-associated proteins. In mouse, the encodedprotein binds to the putative leucine zipper domain of macroH2A1.2,a variant H2A histone that is enriched on inactivated Xchromosomes. The BTB/POZ domain of this protein has been shown inother proteins to mediate transcriptional repression and tointeract with components of histone deacetylase co-repressorcomplexes. Alternative splicing of this gene results in multipletranscript variants encoding the same protein. [provided byRefSeq].
- 1: Rose, J. Phd, et al. Mol. Med. (2010) In press :
- 2: Zhuang, M., et al. Mol. Cell 36(1):39-50(2009)
- 3: Liu, J., et al. Science 323(5918):1218-1222(2009)
- 4: Bunce, M.W., et al. J. Biol. Chem. 283(13):8678-8686(2008)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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