Smad3 (phospho Ser425) Antibody
CATALOG NUMBER: 79-237- Clonality: Polyclonal
- Tested Applications: IHC
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: Smad3 (Phospho-Ser425) antibody was raised against a peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S (p) ) derived from Human Smad3.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC
- APPLICATION NOTE: Immunohistochemistry: 1:50~1:100
- SPECIFICITY: This antibody detects endogenous level of Smad3 only when phosphorylated at serine 425.
- PREDICTED MOLECULAR WEIGHT: 52 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: SMAD3
- ADDITIONAL NAMES: LDS3, LDS1C, MADH3, JV15-2, HSPC193, HsT17436, PTP2C, SHPTP2, MAD-3, Mad3, Mothers against DPP homolog 3
- Protein Accession Number: NP_001138574.1
- PROTEIN GI NUMBER: 223029440
- NCBI GENE ID NUMBER: 4088
Background
- Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
- 1: Shi W, et al. J Cell Sci. 2007 Apr 1;120 (Pt 7): 1216-24Seong HA, et al. J Biol Chem. 2007 Apr 20;282 (16): 12272-89Wordinger RJ, et al. Invest Ophthalmol Vis Sci. 2007 Mar;48 (3): 1191-200LeClair RJ, et al. Circ Res. 2007 Mar 30;100 (6): 826-33
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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