- Trial Size
SEPT1 Antibody
CATALOG NUMBER: 6903- Clonality: Polyclonal
- Tested Applications: E, ICC, IF, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (100%)
- IMMUNOGEN: SEPT1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SEPT1.
The immunogen is located within amino acids 300 - 350 of SEPT1. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, ICC, IF, WB
- APPLICATION NOTE: SEPT1 antibody can be used for detection of SEPT1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - SPECIFICITY: At least two isoforms of SEPT1 are known to exist. This antibody is predicted to not cross-react with other Septin protein family members.
- POSITIVE CONTROL 1: Cat. No. 1207 - Raji Cell Lysate
- POSITIVE CONTROL 2: Cat. No. 17-007 - Raji Cell Slide
Properties
- PURIFICATION: SEPT1 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: SEPT1 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: SEPT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: SEPT1
- ADDITIONAL NAMES: SEPT1 Antibody: LARP, SEP1, DIFF6, PNUTL3, Septin-1, LARP
- Protein Accession Number: NP_443070
- PROTEIN GI NUMBER: 431822382
- NCBI GENE ID NUMBER: 1731
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- SEPT1 Antibody: SEPT1 (also known as Septin 1), is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. SEPT1 was initially identified through yeast two-hybrid screening as an interaction partner for the serine/threonine kinase Aurora-B. During mitosis, SEPT1 localizes to the spindle pole, suggesting that it may play a role in cytokinesis and chromosome congression.
- 1: Qi M, Yu W, Liu S, et al. Septin1, a new interaction partner for human serine/threonine kinase aurora-B. Biochem. Biophys. Res. Commun. 2005; 336:994-1000.
- 2: Russell SE and Hall PA. Septin genomics: a road less travelled. Biol. Chem. 2011; 392:763-7.
- 3: Zhu J, Qi ST, Wang YP, et al. Septin1 is required for spindle assembly and chromosome congression in mouse oocytes. Dev. Dyn. 2011; 240:2281-9.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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