SECISBP2 Antibody
CATALOG NUMBER: 58-088- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat
- IMMUNOGEN: This SECISBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the Central region of human SECISBP2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 95 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: SECISBP2
- ADDITIONAL NAMES: Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2
- Protein Accession Number: Q96T21
- PROTEIN GI NUMBER: 52788293
- NCBI GENE ID NUMBER: 79048
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The incorporation of selenocysteine into a proteinrequires the concerted action of an mRNA element called a secinsertion sequence (SECIS), a selenocysteine-specific translationelongation factor and a SECIS binding protein. With these elementsin place, a UGA codon can be decoded as selenocysteine. The genedescribed in this record encodes a nuclear protein that functionsas a SECIS binding protein. Mutations in this gene have beenassociated with a reduction in activity of a specific thyroxinedeiodinase, a selenocysteine-containing enzyme, and abnormalthyroid hormone metabolism.
- 1: Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)
- 2: Papp, L.V., et al. Antioxid. Redox Signal. 12(7):797-808(2010)
- 3: Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94(10):4003-4009(2009)
- 4: Olieric, V., et al. Biochimie 91(8):1003-1009(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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