- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: Rabbit polyclonal SDPR antibody was raised against an 18 amino acid peptide near the amino terminus of human SDPR.
The immunogen is located within the first 50 amino acids of SDPR.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, IHC-P, WB
- APPLICATION NOTE: SDPR antibody can be used for detection of SDPR by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
- SPECIFICITY: It is predicted to not cross-react with other members of the cavin family.
- POSITIVE CONTROL 1: Cat. No. 1201 - HeLa Cell Lysate
- POSITIVE CONTROL 2: Cat. No. 10-901 - Human Spleen Tissue Slide
- PREDICTED MOLECULAR WEIGHT: Predicted: 22, 33, 43 kDa kDa
Observed: 30 kDa
- PURIFICATION: SDPR Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: SDPR Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: SDPR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
- NCBI OFFICIAL SYMBOL: SDPR
- ADDITIONAL NAMES: SDPR Antibody: SDR, CAVIN2, PS-p68, cavin-2, Serum deprivation-response protein, Cavin-2
- Protein Accession Number: NP_004648
- PROTEIN GI NUMBER: 4759082
- NCBI GENE ID NUMBER: 8436
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
- SDPR Antibody: The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.
- 1: Gustincich S, Vatta P, Goruppi S, et al. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics 1999; 57:120-9.
- 2: Hansen CG, Bright NA, Howard G, et al. SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 2009; 11:807-14.
- 3: Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page.
- Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CATALOG NUMBER: 7265
- Size: 0.02 mg | 0.1 mg
- List Price: $89.00 – $395.00
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