- Recombinant
SARS-CoV-2 Spike RBD Neutralizing Antibody, monoclonal
CATALOG NUMBER: 11-590- Clonality: Recombinant Monoclonal
- Tested Applications: ELISA, WB
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.1 mg
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- SPECIES REACTIVITY: Human
- IMMUNOGEN: Anti-SARS-CoV-2 RBD Neutralizing Antibody, Human IgG1 is isolated from a SARS-CoV-2 infected patient and is recombinantly produced from human 293 cells (HEK293). This antibody recognizes the SARS-CoV-2 Spike Protein RBD domain and inhibits the interaction between SARS-CoV-2 RBD and ACE2 with an IC50 of 1.47 ug/mL using SARS-CoV-2 Inhibitor Screening Kit .Pseudovirus assay shows that this antibody has potent neutralizing activity against pseudovirus bearing SARS-CoV-2 Spike protein.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, WB
- SPECIFICITY: This product is a specific antibody against SARS-CoV-2 Spike protein RBD domain. No cross-reactivity is detected with Spike protein RBD domain of other coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.
Properties
- PURIFICATION: >95% as determined by SDS-PAGE.
- CLONALITY: Recombinant Monoclonal
- ISOTYPE: Human IgG1/kappa
- PHYSICAL STATE: Lyophilized
- BUFFER: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: For long term storage, the product should be stored at lyophilized state at -20°C or lower..Please avoid repeated freeze-thaw cycles.This product is stable after storage at:.-20 to -70°C for 12 months in lyophilized state from date of receipt;.-70°C for 3 months under sterile conditions after reconstitution.
Additional Info
- NCBI OFFICIAL SYMBOL: S
- ADDITIONAL NAMES: spike glycoprotein
- NCBI GENE ID NUMBER: 43740568
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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