• Skip to main content
  • Skip to footer
Close Hamburger Menu Close Hamburger Menu
  • New / Featured Products
  • Advanced Validation
  • Support
  • Promotions
  • Loyalty Program
  • Blog
  • About Us
  • ProSci Distributors

ProSci Incorporated

  • (888) 513-9525
  • Search Icon Open Search Box
  • Sign In
  • Cart Icon
  • Open Hamburger Menu Open Hamburger Menu
  • COVID-19
  • Products
    • Primary Antibodies
    • Secondary Antibodies
    • More
      • Antibody Beads
      • Control Antibodies
      • Detection Sets
      • Immunoblots
      • Lysates
      • Peptides
      • Reagents
      • Recombinant Proteins
      • Slides
      • Chemical
      • Drug Analogues
  • Custom Services
  • Applications & Techniques
  • Contact
  • New / Featured Products
  • Advanced Validation
  • Support
  • Promotions
  • Loyalty Program
  • Blog
  • About Us
  • ProSci Distributors
Home / By Type / Monoclonal / SARS-CoV-2 Spike P681H Antibody [7C11H11] (Omicron, Alpha Variant)
SARS-CoV-2 Spike P681H Antibody [7C11H11] (Omicron, Alpha Variant)SARS-CoV-2 Spike P681H Antibody [7C11H11] (Alpha, Mu Variant)SARS-CoV-2 Spike P681H Antibody [7C11H11] (Alpha, Mu Variant)SARS-CoV-2 Spike P681H Antibody [7C11H11] (Alpha, Mu Variant)
SARS-CoV-2 Spike P681H Antibody [7C11H11] (Omicron, Alpha Variant)
SARS-CoV-2 Spike P681H Antibody [7C11H11] (Alpha, Mu Variant)
SARS-CoV-2 Spike P681H Antibody [7C11H11] (Alpha, Mu Variant)
SARS-CoV-2 Spike P681H Antibody [7C11H11] (Alpha, Mu Variant)
  • New
  • Trial Size

SARS-CoV-2 Spike P681H Antibody [7C11H11] (Omicron, Alpha Variant)

CATALOG NUMBER: PM-9375
  • Clonality: Monoclonal
  • Tested Applications: E, WB
  • Host Species: Mouse
  • Species Reactivity: Virus
  • Conjugate: Unconjugated
  • Size: 0.02 mg | 0.1 mg

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Virus
  • HOMOLOGY: Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (25%)
  • IMMUNOGEN: Anti-SARS-CoV-2 (COVID-19) P681H Mutant Specific Spike P681H antibody (PM-9375) was raised against a peptide corresponding to 12 amino acids near the center of SARS-CoV-2 Alpha variant (B.1.1.7) Spike protein.
    The immunogen is located within 650-700 amino acids of SARS-CoV-2 Alpha Variant (B.1.1.7, UK) Spike protein.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: E, WB
  • APPLICATION NOTE: WB: 1 μg/mL.
    Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 (COVID-19) P681H Mutant Specific Spike antibody can specifically detect SARS-CoV-2 Alpha Variant (B.1.1.7, UK) S1 protein, but not SARS-CoV-2 WT Spike S1 protein by ELISA and WB. It can also detect mutant peptide (681H), but not WT peptide (681P). All other applications and species not yet tested.
  • SPECIFICITY: May cross-react with several virus of interest (VOI) variant lineages that contains P681H mutation, including B.11.318, B.1.621, B.1.621.1, P.3. But all of these lineages are rarely present in current pandemic.

Properties

  • PURIFICATION: SARS-CoV-2 (COVID-19) Alpha Variant (B.1.1.7, UK) Spike P681H Antibody is affinity chromatography purified via peptide column.
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG2b, Kappa
  • PHYSICAL STATE: Liquid
  • BUFFER: SARS-CoV-2 (COVID-19) P681H Mutant Specific Spike antibody is supplied in PBS containing 0.02% sodium azide.
  • CONCENTRATION: 1 mg/mL
  • STORAGE CONDITIONS: SARS-CoV-2 (COVID-19) P681H Mutant Specific Spike antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

  • NCBI OFFICIAL SYMBOL: S
  • ADDITIONAL NAMES: SARS-CoV-2 (COVID-19) P681H Mutant Specific Spike antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein
  • Protein Accession Number: QHD43416
  • PROTEIN GI NUMBER: 1791269090
  • NCBI GENE ID NUMBER: 43740568
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7 and named as Alpha variant, was discovered in the United Kingdom. This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery. The transmission of alpha variant (B.1.1.7 lineage) was increased at least 50%. Increased severity and higher death rate were also found in apha variant. Alpha variant will not affect the effectiveness of COVID19 vaccine. One of the mutations associated with this lineage is a N501Y in the spike protein of the virus. It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence. B.1.1.7 viruses have also been shown to have a P681H mutation in the cleavage site of spike protein. This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.
  • 1: Duchene et al. Virus Evolution 6(2): veaa061.
  • 2: Gu et al. Science 369(6511):1603-1607
  • 3: Hoffmann et al. Molecular Cell 78(4):779-784.e5
  • 4: Davies et al. Science 372(6538):eabg3055.
  • 5: Davies et al. Nature. 593(7858):270-274.
  • 6: Graham, et al. The Lancet Public Health. 6(5): e335-e345.
  • 7: Horby et al. New & Emerging Threats Advisory Group. 2020;91:264-266.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: PM-9375

  • Size: 0.02 mg | 0.1 mg
  • List Price: $129.00 – $439.00
Clear
Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

New & Featured Products
SARS-CoV-2 Omicron BA.1 Variant Pseudovirus
SARS-CoV-2 Omicron BA.1 Variant Pseudovirus

CATALOG NUMBER: 95-201

SARS-CoV-2 WT Pseudovirus
SARS-CoV-2 WT Pseudovirus

CATALOG NUMBER: 95-200

SARS-CoV-2 (COVID-19) Spike Q493R G496S Q498R N501Y Y505H Antibody (Omicron)
SARS-CoV-2 (COVID-19) Spike Q493R G496S Q498R N501Y Y505H Antibody (Omicron)

CATALOG NUMBER: 9805

Menu

  • Primary Antibodies
  • Secondary Antibodies
  • Recombinant Proteins
  • Applications & Techniques
  • Support
  • Loyalty Program
  • Blog
  • Promotions
  • About Us
  • ProSci Distributors
Custom Antibody Services

Contact

12170 Flint Place
Poway, CA 92064, USA

Phone:   +1 (888) 513-9525
Local:    +1 (858) 513-2638
Fax:       +1 (858) 513-2692

customercare@prosci-inc.com
techsupport@prosci-inc.com

Follow

  • Facebook
  • Twitter
  • LinkedIn
  • Pinterest
  • Instagram
Copyright © 2022 ProSci Incorporated | All Rights Reserved | Terms & Conditions | Privacy Policy | Accessibility Feedback | Design by TinyFrog Technologies
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of cookies.
Accept Reject
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT