- SPECIES: SARS-CoV-2
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Val 16 - Arg 685
- FUSION TAG: His Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This recombinant protein can be used for WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 76.9 kDa
- PURITY: >90% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
- STORAGE CONDITIONS: Lyophilized protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- NCBI OFFICIAL SYMBOL: S
- ADDITIONAL NAMES: S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1
- Protein Accession Number: QHD43416.1
- NCBI GENE ID NUMBER: 43740568
- Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- 1: Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.
- 2: Benvenuto D, et al. J Med Virol. 2020.
- 3: Chang CY, et al. AMB Express. 2020. 10(1):20.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 97-087
- Size: 0.1 mg
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