SARS-CoV-2 (COVID-19) S-trimer (D614G) Recombinant Protein
CATALOG NUMBER: 92-748- Size: 0.05 mg
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- SPECIES: SARS-CoV-2 (COVID-19) Spike Protein
- SOURCE SPECIES: Mammalian cells
- RECOMBINANT PROTEIN SEQUENCE: Cys15-Gln1208(D614G)
- FUSION TAG: C-6His tag
- APPLICATION NOTE: This recombinant protein can be used for biological assays. For research use only.
- PREDICTED MOLECULAR WEIGHT: 136.5kDa, 170-220kDa
Properties
- PURITY: Greater than 95% as determined by reducing SDS-PAGE.
- PHYSICAL STATE: Liquid
- BUFFER: Supplied as a 0.2 uM filtered solution of PBS, pH 7.4
- STORAGE CONDITIONS: Reconstituted protein solution should be store below -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: S
- ADDITIONAL NAMES: 2019-nCov S protein; 2019-nCoV Spike glycoprotein; 2019-nCoV S glycoprotein; SARS-nCoV-2 Spikeglycoprotein
- Protein Accession Number: QHD43416.1
- NCBI GENE ID NUMBER: 43740568
Background
- The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell atthe advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acuterespiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusionrequired for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's beenreported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the humanACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction ofneutralizing-antibody and T-cell responses, as well as protective immunity.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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