- SPECIES: SARS-CoV-2
- SOURCE SPECIES: Mammalian cells
- RECOMBINANT PROTEIN SEQUENCE: Arg319-Phe541
- FUSION TAG: C-His Tag
- TESTED APPLICATIONS: E
- APPLICATION NOTE: Immunogen
- PREDICTED MOLECULAR WEIGHT: 28.03kDa
- BIOLOGICAL ACTIVITY: Recombinant SARS-CoV-2 (COVID-19) S Protein RBD (10-431) can bind Anti-SARS-CoV-2 (S1)-1 antibody (10-706) measured by a functional ELISA assay.The EC50 of Recombinant SARS-CoV-2 (COVID-19) S Protein RBD is 15 ng/ml.
- PURITY: >90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.
- PHYSICAL STATE: Lyophilized
- BUFFER: Supplied as lyophilized from PBS, pH 7.5. Please reconstitute the protein with ddH2O to the concentration with 1mg/ml.
- STORAGE CONDITIONS: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
- ADDITIONAL NAMES: 2019-nCov RBD Protein,2019-nCoV Spike RBD Protein
- Protein Accession Number: YP_009724390.1
- Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- FOR RESEARCH USE ONLY
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- Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
CATALOG NUMBER: 10-431
- Size: 0.1 mg
- List Price: $505.00
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