Specifications
- SPECIES: SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope Protein
- SOURCE SPECIES: E. coli
- RECOMBINANT PROTEIN SEQUENCE: Met1-Val75
- FUSION TAG: N-BBP-6His tag
- APPLICATION NOTE: This recombinant protein can be used for biological assays. For research use only.
- PREDICTED MOLECULAR WEIGHT: 27.5kDa, 22-25kDa
Properties
- PURITY: Greater than 95% as determined by reducing SDS-PAGE.
- PHYSICAL STATE: Liquid
- BUFFER: Supplied as a 0.2 uM filtered solution of 20mM Tris–HCl, 200mM NaCl, pH 8.0
- STORAGE CONDITIONS: Reconstituted protein solution should be store below -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: E
- ADDITIONAL NAMES: 2019-nCoV E protein; 2019-nCoV sM protein
- Protein Accession Number: QHD43418.1
- NCBI GENE ID NUMBER: 43740570
Background
- These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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