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- PREDICTED MOLECULAR WEIGHT: 670.9 . 96.1
- Formula: C38H50N6O5 . CH4SO3
- CAS: 149845-06-7
- Solubility: Soluble in DMSO or DMF. Sparingly soluble in ethanol, methanol or water.
- InChi Key: IRHXGOXEBNJUSN-YOXDLBRISA-N
- Smiles: CS(=O)(O)=O.O[[email protected]@H]([[email protected]@H](NC([[email protected]](CC(N)=O)NC(C1=NC(C=CC=C2)=C2C=C1)=O)=O)CC3=CC=CC=C3)CN4C[[email protected]@]5([H])CCCC[[email protected]@]5([H])C[[email protected]]4C(NC(C)(C)C)=O
- RTECS: EJ6664000
- Identity: Determined by 1H-NMR.
Properties
- PURITY: greater than or equal to 98%
- PHYSICAL STATE: Lyophilized
- STORAGE CONDITIONS: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Additional Info
- ADDITIONAL NAMES: Ro 31-8959
Background
- Saquinavir is an antiretroviral inhibitor of the human immunodeficiency virus. It potently inhibits HIV-1 (Ki=0.12nM) and HIV-2 (Ki<0.1nM) protease in vitro. HIV-1 protease is important for the replication of the virus within the cell and the release of mature viral particles from the infected cell. Formulations containing saquinavir have been used in combination with other inhibitors for the treatment of AIDS. Saquinavir shows other antimicrobial and antiviral activity. Potential SARS-CoV-2 replication inhibitor, responsible for COVID-19. Shows anti-cancer activity. Shown to induce apoptosis, autophagy and endoplasmic reticulum stress, which consequently leads to cancer cell death. Anti-inflammatory agent. Blocks cathepsin V and thereby inhibits disulfide HMGB1-induced TLR4 activation and cytokine production.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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