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- SPECIES: Human
- SOURCE SPECIES: E. coli
- RECOMBINANT PROTEIN SEQUENCE: Met 1 - Gly 90
- FUSION TAG: Tag free
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This recombinant protein can be used for WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 10.2 kDa
- BIOLOGICAL ACTIVITY: The bio-activity of S100A6 was determined by its binding ability with human CEACAM3 protein in the presence of 100 mM CaCl2.
Properties
- PURITY: >95% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: PBS, pH7.4
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: S100A6
- ADDITIONAL NAMES: S100A6, 2A9, 5B10, CABP, CACY, PRA
- Protein Accession Number: AAH01431
- NCBI GENE ID NUMBER: 6277
Background
- S100 calcium binding protein A6 (S100-A6) is also kown as 2A9, 5B10, CABP, CACY and PRA, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100A6 may function in stimulation of Ca2+ -dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. S100A6 has been shown to interact with S100B and SUGT1.
- 1: Deloulme, J C, et al., 2000, J. Biol. Chem. (UNITED STATES) 275 (45): 35302–10.
- 2: Yang, Q, et al., 1999, Exp. Cell Res. (UNITED STATES) 246 (2): 501–9.
- 3: Nowotny, Marcin, et al., 2003, J. Biol. Chem. (United States) 278 (29): 26923–8.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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