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- PREDICTED MOLECULAR WEIGHT: 306.4 . 98.0
- Formula: C17H18N6 . H3O4P
- CAS: 1092939-17-7
- Solubility: Soluble in DMSO (10mg/ml).
- InChi Key: JFMWPOCYMYGEDM-XFULWGLBSA-N
- Smiles: N#CC[[email protected]](C1CCCC1)N(N=C2)C=C2C3=NC=NC4=C3C=CN4.OP(O)(O)=O
- Identity: Determined by 1H-NMR and MS.
Properties
- PURITY: greater than or equal to 98% (HPLC)
- PHYSICAL STATE: Lyophilized
- STORAGE CONDITIONS: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Additional Info
- ADDITIONAL NAMES: INCB018424; INC 424
Background
- Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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