- Trial Size
RPSA Antibody
CATALOG NUMBER: 7605- Clonality: Polyclonal
- Tested Applications: E, IF, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (100%), Rat: (100%), Sheep: (100%)
- IMMUNOGEN: RPSA antibody was raised against a 17 amino acid peptide near the carboxy terminus of human RPSA.
The immunogen is located within amino acids 190 - 240 of RPSA. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, IHC-P, WB
- APPLICATION NOTE: RPSA antibody can be used for detection of RPSA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. - SPECIFICITY: RPSA antibody is human, mouse and rat reactive.
- POSITIVE CONTROL 1: Cat. No. 1223 - Caco-2 Cell Lysate
- PREDICTED MOLECULAR WEIGHT: Predicted: 32 kDa
Observed: 32 kDa
Properties
- PURIFICATION: RPSA antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: RPSA antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: RPSA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: RPSA
- ADDITIONAL NAMES: RPSA Antibody: SA, LBP, LRP, p40, 67LR, ICAS, lamR, 37LRP, LAMBR, LAMR1, LRP/LR, LBP/p40, NEM/1CHD4, 40S ribosomal protein SA, 37 kDa laminin receptor precursor
- Protein Accession Number: NP_002286
- PROTEIN GI NUMBER: 9845502
- NCBI GENE ID NUMBER: 3921
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1). Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2). RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3).
- 1: Jackers P, Minoletti F, Belotti D, et al. Isolation from a multigene family of the active human gene of the metastasis-associated 67kDa laminin binding protein 37LRP/p40 at chromosome 3p21.3. Oncogene 1996; 13:495-503.
- 2: Savino W and Silva-Barbosa SD. Laminin/VLA-6 interactions and T cell function. Braz. J. Med. Biol. Res. 1996; 29:1209-20.
- 3: Kumazoe M, Sugihara K, Tsukamoto S, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J. Clin. Invest. 2013; 123:787-99.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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