RHOC Antibody
CATALOG NUMBER: 57-478- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine
- IMMUNOGEN: This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:2000
- PREDICTED MOLECULAR WEIGHT: 22 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: RHOC
- ADDITIONAL NAMES: Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC
- Protein Accession Number: P08134
- PROTEIN GI NUMBER: 132543
- NCBI GENE ID NUMBER: 389
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a member of the Rho family of smallGTPases, which cycle between inactive GDP-bound and activeGTP-bound states and function as molecular switches in signaltransduction cascades. Rho proteins promote reorganization of theactin cytoskeleton and regulate cell shape, attachment, andmotility. The protein encoded by this gene is prenylated at itsC-terminus, and localizes to the cytoplasm and plasma membrane. Itis thought to be important in cell locomotion. Overexpression ofthis gene is associated with tumor cell proliferation andmetastasis. Multiple alternatively spliced variants, encoding thesame protein, have been identified.
- 1: Jiang, L., et al. Int. J. Cancer 127(3):505-512(2010)
- 2: Wu, M., et al. Cancer 116 (11 SUPPL), 2768-2782 (2010) :
- 3: Lipkin, S.M., et al. Cancer Prev Res (Phila) 3(5):597-603(2010)
- 4: Kitzing, T.M., et al. Oncogene 29(16):2441-2448(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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