- SPECIES: Rhesus monkey
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Leu 19 - Arg 170
- FUSION TAG: His Tag
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.3 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 19.3 kDa
- PURITY: >90% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: 100 mM Acetic Acid, pH2.5
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- NCBI OFFICIAL SYMBOL: PGF
- ADDITIONAL NAMES: PGF,PLGF,PlGF,PGFL,SHGC-10760
- Protein Accession Number: XP_001096010.1
- NCBI GENE ID NUMBER: 701219
- Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
- 1: Maglione D., et al., 1993, Oncogene 8 (4): 925–31.
- 2: Khalil A., et al., 2008, PLoS ONE 3 (7): e2766.
- 3: Khurana R., et al., 2005, Circulation 111 (21): 2828–2836.
- 4: Rolny C., et al., 2011, Cancer Cell 19:31-44.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 11-489
- Size: 0.05 mg
- List Price: $505.00
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