Rhesus macaque / Complement Factor D / CFD Recombinant Protein
CATALOG NUMBER: 11-370- Tested Applications: WB
- Size: 0.1 mg
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- SPECIES: Cynomolgus, Rhesus macaque
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Ile 26 - Ala 253
- FUSION TAG: His Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.5 kDa. The protein migrates as 25-27 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 26.5 kDa
Properties
- PURITY: >90% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: 50 mM Tris, 150 mM NaCl, pH8.0
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: CFD
- ADDITIONAL NAMES: CFD,Adipsin,PFD,DF,Complement factor D
- Protein Accession Number: XP_005587397.1
- NCBI GENE ID NUMBER: 102136571
Background
- Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
- 1: White R.T., et al., 1992, J. Biol. Chem. 267:9210-9213.
- 2: Johnson D.M.A., et al., 1984, FEBS Lett. 166:347-351.
- 3: Sprong T., et al., 2006, Blood 107:4865-4870.
Disclaimer
- FOR RESEARCH USE ONLY
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