Specifications
- SPECIES: Human, Cynomolgus, Rhesus macaque
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Asn 19 - Pro 152
- FUSION TAG: Mouse IgG Fc Tag
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.0 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 42.0 kDa
Properties
- PURITY: >95% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: 50 mM Tris, 100 mM Glycine, pH7.5
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: CD28
- ADDITIONAL NAMES: CD28,Tp44
- Protein Accession Number: NP_006130.1
- NCBI GENE ID NUMBER: 940
Background
- T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
- 1: Evans E.J., et al., 2005, Nat. Immunol. 6:271-279.
- 2: Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46.
- 3: Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
Disclaimer
- FOR RESEARCH USE ONLY
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