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Home / Cancer / RheB Recombinant Protein

RheB Recombinant Protein

CATALOG NUMBER: 92-154

    Specifications

    • SPECIES: Human
    • SOURCE SPECIES: E. coli
    • RECOMBINANT PROTEIN SEQUENCE: Met1-Met184
    • FUSION TAG: N-GST tag
    • APPLICATION NOTE: This recombinant protein can be used for biological assays. For research use only.
    • PREDICTED MOLECULAR WEIGHT: 20.4 kD

    Properties

    • PURITY: Greater than 95% as determined by reducing SDS-PAGE.
      Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
    • PHYSICAL STATE: Lyophilized
    • BUFFER: Lyophilized from a 0.2 um filtered solution of 20mM Tris, 10mM GSH, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
    • STORAGE CONDITIONS: Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks.
      Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
      Aliquots of reconstituted samples are stable at -20°C for 3 months.

    Additional Info

    • NCBI OFFICIAL SYMBOL: RHEB
    • ADDITIONAL NAMES: GTP-Binding Protein Rheb, Ras Homolog Enriched in Brain, RHEB, RHEB2
    • Protein Accession Number: Q15382
    • NCBI GENE ID NUMBER: 6009

    Background

    • GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, farnesylation of the protein is required for this activity.

    Disclaimer

    • FOR RESEARCH USE ONLY
      For additional information, visit ProSci's Terms & Conditions Page.
    • Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

    CATALOG NUMBER: 92-154

      Product Discontinued. Please contact us for alternate product(s).

      Datasheet
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