- HOST SPECIES: Human
- SPECIES REACTIVITY: Virus
- IMMUNOGEN: full length recombinant S Protein
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E
- APPLICATION NOTE: Immunoreactivity: 80–120 % compared to the reference sample in an ELISA test.
- SPECIFICITY: Antibody recognizes 2019-nCoV S-RBD Protein.
- PURIFICATION: ≥95 %
- CLONALITY: Recombinant Monoclonal
- ISOTYPE: Human IgG1
- PHYSICAL STATE: Liquid
- BUFFER: PBS, pH 7.4
- CONCENTRATION: 5.0 mg/ml (+/- 10 %)
- STORAGE CONDITIONS: 24 months from manufacturing at <-20 °C; 1 month, 2 to 8 °C under sterile conditions.
- NCBI OFFICIAL SYMBOL: S
- ADDITIONAL NAMES: SARS-CoV-2 (COVID-19) Spike S1 Antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein
- Protein Accession Number: QHD43416
- PROTEIN GI NUMBER: 1791269090
- NCBI GENE ID NUMBER: 43740568
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
- The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- FOR RESEARCH USE ONLY
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- Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CATALOG NUMBER: 93-309
- Size: 0.1 mg
- List Price: $440.00
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