- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- IMMUNOGEN: A synthetic peptide of human RAN
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, IHC, WB
- APPLICATION NOTE: WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
Flow: 1:20 - 1:50
- POSITIVE CONTROL 1: HL-60
- PREDICTED MOLECULAR WEIGHT: Observed: 22kDa
- PURIFICATION: Affinity purification
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: PBS with 0.02% sodium azide, pH7.3.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C. Avoid freeze / thaw cycles.
- NCBI OFFICIAL SYMBOL: RAN
- ADDITIONAL NAMES: member RAS oncogene, guanosine triphosphatase Ran, androgen receptor-associated protein 24, RanGTPase, OTTHUMP00000166078, OK/SW-cl.81, GTPase Ran, GTP-binding nuclear protein Ran, TC4, Gsp1, ARA24, RAN, member RAS oncogene family
- NCBI GENE ID NUMBER: 5901
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
- RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
- FOR RESEARCH USE ONLY
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- Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CATALOG NUMBER: 13-288
- Size: 100 uL
- List Price: $365.00
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