PYDC1 Antibody
CATALOG NUMBER: 56-864- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This PYDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the Central region of human PYDC1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 10 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: PYDC1
- ADDITIONAL NAMES: Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1
- Protein Accession Number: Q8WXC3
- PROTEIN GI NUMBER: 74730989
- NCBI GENE ID NUMBER: 260434
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
- 1: Son, Y.L., et al. Biochem. J. 410(2):319-330(2008)
- 2: Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006)
- 3: Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006)
- 4: Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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