PPARD Antibody
CATALOG NUMBER: 57-265- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human PPARD.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 50 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: PPARD
- ADDITIONAL NAMES: Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
- Protein Accession Number: Q03181
- PROTEIN GI NUMBER: 417522
- NCBI GENE ID NUMBER: 5467
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a member of the peroxisomeproliferator-activated receptor (PPAR) family. PPARs are nuclearhormone receptors that bind peroxisome proliferators and controlthe size and number of peroxisomes produced by cells. PPARs mediatea variety of biological processes, and may be involved in thedevelopment of several chronic diseases, including diabetes,obesity, atherosclerosis, and cancer. This protein is a potentinhibitor of ligand-induced transcription activity of PPAR alphaand PPAR gamma. It may function as an integrator of transcriptionrepression and nuclear receptor signaling. The expression of thisgene is found to be elevated in colorectal cancer cells. Theelevated expression can be repressed by adenomatosis polyposis coli(APC), a tumor suppressor protein related to APC/beta-cateninsignaling pathway. Knockout studies in mice suggested the role ofthis protein in myelination of the corpus callosum, lipidmetabolism, and epidermal cell proliferation. Alternate splicingresults in multiple transcript variants.
- 1: Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- 2: Christopoulos, P., et al. Ann. N. Y. Acad. Sci. 1205, 185-191 (2010) :
- 3: Dunn, S.E., et al. J. Exp. Med. 207(8):1599-1608(2010)
- 4: Eynon, N., et al. Mitochondrion (2010) In press :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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