POLK Antibody
CATALOG NUMBER: 60-812- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This POLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the Central region of human POLK.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 99 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: POLK
- ADDITIONAL NAMES: DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
- Protein Accession Number: Q9UBT6
- PROTEIN GI NUMBER: 59798438
- NCBI GENE ID NUMBER: 51426
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- External and internal DNA-damaging agents continuallythreaten the integrity of genetic material in cells. Although avariety of repair mechanisms exist to remove the resulting lesions,some lesions escape repair and block the replication machinery.Members of the Y family of DNA polymerases, such as POLK, permitthe continuity of the replication fork by allowing replicationthrough such DNA lesions. Each Y family polymerase has a uniqueDNA-damage bypass and fidelity profile. POLK is specialized for theextension step of lesion bypass (summary by Lone et al., 2007[PubMed 17317631]).
- 1: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 2: Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
- 3: Katafuchi, A., et al. Nucleic Acids Res. 38(3):859-867(2010)
- 4: Fukuda, H., et al. J. Biol. Chem. 284(38):25585-25592(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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