PNKP Antibody
CATALOG NUMBER: 57-487- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This PNKP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the N-terminal region of human PNKP.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 57 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: PNKP
- ADDITIONAL NAMES: Bifunctional polynucleotide phosphatase/kinase, DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase, Polynucleotide 3'-phosphatase, 2'(3')-polynucleotidase, Polynucleotide 5'-hydroxyl-kinase, PNKP
- Protein Accession Number: Q96T60
- PROTEIN GI NUMBER: 50401132
- NCBI GENE ID NUMBER: 11284
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This locus represents a gene involved in DNA repair. Inresponse to ionizing radiation or oxidative damage, the proteinencoded by this locus catalyzes 5' phosphorylation and 3'dephosphorylation of nucleic acids. Mutations at this locus havebeen associated with microcephaly, seizures, and developmentaldelay.
- 1: Arora, M., et al. Leukemia 24(8):1470-1475(2010)
- 2: Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)
- 3: Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
- 4: Shen, J., et al. Nat. Genet. 42(3):245-249(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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