PKR (Ab 451) Antibody
CATALOG NUMBER: 79-399- Clonality: Polyclonal
- Tested Applications: IF, IHC
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: PKR (Ab-451) antibody was raised against a peptide sequence around aa.449~453 (K-G-T-L-R) derived from Human PKR.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IHC
- APPLICATION NOTE: Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
- SPECIFICITY: This antibody detects endogenous level of total PKR protein.
- PREDICTED MOLECULAR WEIGHT: 68 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: EIF2AK2
- ADDITIONAL NAMES: PKR, PRKR, EIF2AK1, CBL2, RNF55, ADRB2, E2AK2, EIF2AK2, EIF2aK
- Protein Accession Number: NP_001129123.1
- PROTEIN GI NUMBER: 208431827
- NCBI GENE ID NUMBER: 5610
Background
- Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
- 1: Ingrid K. Ruf, et, al. (2005) J. Virol ; 79: 14562 - 14569. Christy M. Hebner, et, al. (2006) J. Gen. Virol ; 87: 3183 - 3193. Rika van Huizen, et, al. (2003) J. Biol. Chem ; 278: 15558 - 15564.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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