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Phosphotyrosine Antibody [PY20] (PE)
CATALOG NUMBER: 98-518- Clonality: Monoclonal
- Tested Applications: ELISA
- Host Species: Mouse
- Conjugate: PE
- Size: 0.1 mg
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- HOST SPECIES: Mouse
- IMMUNOGEN: Phosphotyrosine conjugated to carrier proteins
- CONJUGATE: PE
- TESTED APPLICATIONS: ELISA
- APPLICATION NOTE: Phosphotyrosine Antibody [PY20] for use in flow cytometry assays.
- SPECIFICITY: Phosphotyrosine
Properties
- CLONALITY: Monoclonal
- ISOTYPE: IgG2b
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS/NaN3 and a stabilizing agent
- CONCENTRATION: 0.1 mg/mL
- STORAGE CONDITIONS: Store vial at 2-8°C
Additional Info
- ADDITIONAL NAMES: pTyr20
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Protein tyrosine residues are phosphorylated as a result of intracellular protein kinase activation (e.g., via growth factors) during normal growth and development and in oncogenesis. The most abundant population of target proteins for tyrosine phosphorylation is cell surface glycoproteins. Antibodies to phosphotyrosine enable the detection, isolation, and characterization of proteins containing phosphotyrosine. The monoclonal antibody PY20 prevents internalization of activated receptors (e.g., EGFR) when microinjected into cells. The affinity of PY20 for phosphotyrosine is approximately 10-6 to 10-7 M. PY20 binding to phosphorylated tyrosines can be inhibited by free phosphotyrosine and phenylphosphate but not by phosphoserine, phosphothreonine, or free phosphate.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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