PDGFRa (phospho Tyr849) Antibody
CATALOG NUMBER: 79-964- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: PDGFRa (phospho Tyr849) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine849 (S-N-Y (p)-V-S) derived from Human PDGFRa.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: The antibody detects endogenous level of PDGFRa only when phosphorylated at tyrosine 849.
- PREDICTED MOLECULAR WEIGHT: 140 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: PDGFRA
- ADDITIONAL NAMES: CD140a, PDGFR-alpha, PGFRA, kinase PDGFR-alpha,
- Protein Accession Number: NP_006197.1
- PROTEIN GI NUMBER: 129892
- NCBI GENE ID NUMBER: 5156
Background
- Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.
- 1: Rikova K, et al. (2007) Cell 131, 1190-203
- 2: Moritz A, et al. (2010) Sci Signal 3, ra64
- 3: Guo A, et al. (2008) Proc Natl Acad Sci U S A 105, 692-7
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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