PCSK6 Antibody
CATALOG NUMBER: 58-025- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This PCSK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-688 amino acids from the C-terminal region of human PCSK6.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 106 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit IgG
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: PCSK6
- ADDITIONAL NAMES: Proprotein convertase subtilisin/kexin type 6, 3421-, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, SPC4, Subtilisin/kexin-like protease PACE4, PCSK6, PACE4
- Protein Accession Number: P29122
- PROTEIN GI NUMBER: 129542
- NCBI GENE ID NUMBER: 5046
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene belongs to thesubtilisin-like proprotein convertase family. The members of thisfamily are proprotein convertases that process latent precursorproteins into their biologically active products. This encodedprotein is a calcium-dependent serine endoprotease that can cleaveprecursor protein at their paired basic amino acid processingsites. Some of its substrates are - transforming growth factor betarelated proteins, proalbumin, and von Willebrand factor. This geneis thought to play a role in tumor progression. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.
- 1: Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- 2: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 3: Fuller, J.A., et al. Invest. Ophthalmol. Vis. Sci. 50(12):5759-5768(2009)
- 4: Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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