PCBP1 Antibody
CATALOG NUMBER: 60-150- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 400 ul
Powered by BiozSpecifications
- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine, Rabbit
- IMMUNOGEN: This PCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the Central region of human PCBP1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 37 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: PCBP1
- ADDITIONAL NAMES: Poly(rC)-binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB23, PCBP1
- Protein Accession Number: Q15365
- PROTEIN GI NUMBER: 42560548
- NCBI GENE ID NUMBER: 5093
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This intronless gene is thought to have been generated byretrotransposition of a fully processed PCBP-2 mRNA. This gene andPCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to havearisen as a result of duplication events of entire genes. Theprotein encoded by this gene appears to be multifunctional. Italong with PCBP-2 and hnRNPK corresponds to the major cellularpoly(rC)-binding protein. It contains three K-homologous (KH)domains which may be involved in RNA binding. This encoded proteintogether with PCBP-2 also functions as translational coactivatorsof poliovirus RNA via a sequence-specific interaction withstem-loop IV of the IRES and promote poliovirus RNA replication bybinding to its 5'-terminal cloverleaf structure. It has also beenimplicated in translational control of the 15-lipoxygenase mRNA,human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.The encoded protein is also suggested to play a part in formationof a sequence-specific alpha-globin mRNP complex which isassociated with alpha-globin mRNA stability.
- 1: Cloke, B., et al. Endocrinology 151(8):3954-3964(2010)
- 2: Wang, H., et al. Cancer Cell 18(1):52-62(2010)
- 3: Zhang, T., et al. Mol. Cancer 9, 72 (2010) :
- 4: Waggoner, S.A., et al. J. Biol. Chem. 284(14):9039-9049(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
New & Featured Products
![HIV-1 p24 Antibody [10A2] (biotin)](https://www.prosci-inc.com/wp-content/uploads/2023/01/HIV-1-p24-Antibody-10A2_WB_PM-7371.gif){kind=small}
HIV-1 p24 Antibody [10A2] (biotin)
CATALOG NUMBER: PM-7371-biotin
![HIV-1 p24 Antibody [9D2F6] (biotin)](https://www.prosci-inc.com/wp-content/uploads/2023/01/HIV-1-p24-Antibody-9D2F6_WB_PM-7369.gif){kind=small}
HIV-1 p24 Antibody [9D2F6] (biotin)
CATALOG NUMBER: PM-7369-biotin
![HIV-1 p24 Antibody [8D7E11] (biotin)](https://www.prosci-inc.com/wp-content/uploads/2023/01/HIV-1-p24-Antibody-8D7E11_WB_PM-7367.gif){kind=small}
HIV-1 p24 Antibody [8D7E11] (biotin)
CATALOG NUMBER: PM-7367-biotin