Specifications
- SPECIES: Human
- SOURCE SPECIES: Sf21 cells
- RECOMBINANT PROTEIN SEQUENCE: Human full-length PARP-3 [ARTD3] is fused to a HA-tag and a His-tag.
- FUSION TAG: His Tag
- APPLICATION NOTE: This recombinant proteins is for research use only.
- BIOLOGICAL ACTIVITY: >10U/mg protein (only monoADP-ribosyl transferase activity).
Properties
- PURITY: >98% (SDS-PAGE)
- PHYSICAL STATE: Liquid
- BUFFER: In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
- CONCENTRATION: Lot dependent (0.2-1mg/ml)
- STORAGE CONDITIONS: Stable for at least 6 months after receipt when stored at -80°C.
Additional Info
- NCBI OFFICIAL SYMBOL: PARP3
- ADDITIONAL NAMES: Poly(ADP-ribose) Polymerase 3, ADP-ribosyltransferase Diphtheria Toxin-like 3, NAD(+) ADP-ribosyltransferase 3
- Protein Accession Number: Q9Y6F1
- PROTEIN GI NUMBER: 158634478
- NCBI GENE ID NUMBER: 10039
Background
- PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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