PADI2 Antibody
CATALOG NUMBER: 57-682- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This PADI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-586 amino acids from the C-terminal region of human PADI2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 76 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: PADI2
- ADDITIONAL NAMES: Protein-arginine deiminase type-2, PAD-H19, Peptidylarginine deiminase II, Protein-arginine deiminase type II, PADI2, KIAA0994, PDI2
- Protein Accession Number: Q9Y2J8
- PROTEIN GI NUMBER: 7531171
- NCBI GENE ID NUMBER: 11240
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a member of the peptidyl argininedeiminase family of enzymes, which catalyze the post-translationaldeimination of proteins by converting arginine residues intocitrullines in the presence of calcium ions. The family membershave distinct substrate specificities and tissue-specificexpression patterns. The type II enzyme is the most widelyexpressed family member. Known substrates for this enzyme includemyelin basic protein in the central nervous system and vimentin inskeletal muscle and macrophages. This enzyme is thought to play arole in the onset and progression of neurodegenerative humandisorders, including Alzheimer disease and multiple sclerosis, andit has also been implicated in glaucoma pathogenesis. This geneexists in a cluster with four other paralogous genes. [provided byRefSeq].
- 1: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 2: Jang, B., et al. Acta Neuropathol. 119(2):199-210(2010)
- 3: Cafaro, T.A., et al. Mol. Vis. 16, 1654-1658 (2010) :
- 4: Hojo-Nakashima, I., et al. J. Biochem. 146(4):471-479(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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