p53 (phospho Ser392) Antibody
CATALOG NUMBER: 80-018- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: p53 (phospho Ser392) antibody was raised against a peptide sequence around phosphorylation site of serine 392 (P-D-S (p)-D) derived from Human p53.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: The antibody detects endogenous level of p53 only when phosphorylated at serine 392.
- PREDICTED MOLECULAR WEIGHT: 53 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: TP53
- ADDITIONAL NAMES: Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, Tumor suppressor p53
- Protein Accession Number: NP_000537.3
- PROTEIN GI NUMBER: 120407068
- NCBI GENE ID NUMBER: 7157
Background
- Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
- 1: Choi DW, et al. (2013) Mol Cell 51, 374-85
- 2: Bagashev A, et al. (2013) Cell Cycle 12, 1569-77
- 3: Shahar OD, et al. (2013) PLoS One 8, e78472
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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